Social media and sentiment in bioenergy consultation

Purpose: The push to widen participation in public consultation suggests social media as an additional mechanism through which to engage the public. Bioenergy companies need to build their capacity to communicate in these new media and to monitor the attitudes of the public and opposition organisations towards energy development projects. Design/methodology/approach: This short paper outlines the planning issues bioenergy developments face and the main methods of communication used in the public consultation process in the UK. The potential role of social media in communication with stakeholders is identified. The capacity of sentiment analysis to mine opinions from social media is summarised, and illustrated using a sample of tweets containing the term ‘bioenergy’ Findings: Social media have the potential to improve information flows between stakeholders and developers. Sentiment analysis is a viable methodology, which bioenergy companies should be using to measure public opinion in the consultation process. Preliminary analysis shows promising results. Research limitations/implications: Analysis is preliminary and based on a small dataset. It is intended only to illustrate the potential of sentiment analysis and not to draw general conclusions about the bioenergy sector. Originality/value: Opinion mining, though established in marketing and political analysis, is not yet systematically applied as a planning consultation tool. This is a missed opportunity

Multi-dwelling Refurbishment Optimization: Problem Decomposition, Solution, and Trade-off Analysis

A methodology has been developed for the multiobjective optimization of the refurbishment of domestic building stock on a regional scale. The approach is based on the decomposition of the problem into two stages: first to find the energy-cost trade-off for individual houses, and then to apply it tomultiple houses. The approach has been applied to 759 dwellings using buildings data from a survey of the UK housing stock. The energy use of each building and their refurbished variants were simulated using EnergyPlus using automatically-generated input files. The variation in the contributing refurbishment options from least to highest cost along the Pareto front shows loft and cavity wall insulation to be optimal intially, and solid wall insulation and double glazing appearing later

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry

Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their proteins remains unclear. Here we show that knockdown (KD) of RPGR, RPGRIP1 or RPGRIP1L in hTERT-RPE1 cells results in abnormal actin cytoskeleton organization. The actin cytoskeleton rearrangement is regulated by the small GTPase RhoA via the planar cell polarity (PCP) pathway. RhoA activity was upregulated in the absence of RPGR, RPGRIP1 or RPGRIP1L proteins. In RPGR, RPGRIP1 or RPGRIP1L KD cells, we observed increased levels of DVl2 and DVl3 proteins, the core components of the PCP pathway, due to impaired proteasomal activity. RPGR, RPGRIP1 or RPGRIP1L KD cells treated with thapsigargin (TG), an inhibitor of sarcoendoplasmic reticulum Ca2+ - ATPases, showed impaired store-operated Ca2+ entry (SOCE), which is mediated by STIM1 and Orai1 proteins. STIM1 was not localized to the ER-PM junction upon ER store depletion in RPGR, RPGRIP1 or RPGRIP1L KD cells. Our results demonstrate that the RPGR protein complex is required for regulating proteasomal activity and for modulating SOCE, which may contribute to the ciliopathy phenotype

Divergent Changes in Plant Community Composition under 3-Decade Grazing Exclusion in Continental Steppe

An understanding of the factors controlling plant community composition will allow improved prediction of the responses of plant communities to natural and anthropogenic environmental change. Using monitoring data from 1980 to 2009, we quantified the changes in community composition in Leymus chinensis and Stipa grandis dominated grasslands in Inner Mongolia under long-term grazing-exclusion and free-grazing conditions, respectively. We demonstrated that the practice of long-term grazing exclusion has significant effects on the heterogeneity, the dominant species, and the community composition in the two grasslands. The community composition of L. chinensis and S. grandis grasslands exhibited directional changes with time under long-term grazing exclusion. Under free grazing, the L. chinensis community changed directionally with time, but the pattern of change was stochastic in the S. grandis community. We attributed the divergent responses to long-term grazing exclusion in the S. grandis and L. chinensis grasslands to litter accumulation and changes in the microenvironment after grazing exclusion, which collectively altered the growth and regeneration of the dominant species. The changes in the grazed grasslands were primarily determined by the selective feeding of sheep during long-term heavy grazing. Overall, the responses of the community composition of the Inner Mongolian grasslands to long-term grazing exclusion and heavy grazing were divergent, and depended primarily on the grassland type. Our findings provide new insights into the role of grazing in the maintenance of community structure and function and therefore have important implications for grassland management

Novel properties and potential applications of functional ligand-modified polyoxotitanate cages.

Functional ligand-modified polyoxotitanate (L-POT) cages of the general type [TixOy(OR)z(L)m] (OR = alkoxide, L = functional ligand) can be regarded as molecular fragments of surface-sensitized solid-state TiO2, and are of value as models for studying the interfacial charge and energy transfer between the bound functional ligands and a bulk semiconductor surface. These L-POTs have also had a marked impact in many other research fields, such as single-source precursors for TiO2 deposition, inorganic-organic hybrid material construction, photocatalysis, photoluminescence, asymmetric catalysis and gas adsorption. Their atomically well-defined structures provide the basis for the understanding of structure/property relationships and ultimately for the rational design of new cages targeting specific uses. This highlight focuses on recent advances in L-POTs research, with emphasis on their novel properties and potential applications.EPSRCThis is the final version of the article. It first appeared from Royal Society of Chemistry via https://doi.org/10.1039/C6CC03788G

Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.

Common Variable Immunodeficiency Disorders (CVIDs) are the most prevalent cause of primary antibody failure. CVIDs are highly variable and a genetic causes have been identified in <5% of patients. Here, we performed whole genome sequencing (WGS) of 34 CVID patients (94% sporadic) and combined them with transcriptomic profiling (RNA-sequencing of B cells) from three patients and three healthy controls. We identified variants in CVID disease genes TNFRSF13B, TNFRSF13C, LRBA and NLRP12 and enrichment of variants in known and novel disease pathways. The pathways identified include B-cell receptor signalling, non-homologous end-joining, regulation of apoptosis, T cell regulation and ICOS signalling. Our data confirm the polygenic nature of CVID and suggest individual-specific aetiologies in many cases. Together our data show that WGS in combination with RNA-sequencing allows for a better understanding of CVIDs and the identification of novel disease associated pathways

The heating performance of air-source-heat-pumps in the retrofit of domestic buildings

The adoption of Air-to-Water Heat Pumps (AWHPs) is a promising retrofit strategy for reducing heating energy consumption and decarbonizing domestic heating in temperate climates. In this paper, an AWHP with supplementary electric heating has been employed as a retrofit heating strategy for 756 house archetypes, which have been selected to represent the housing stock of the North-East region of England. The objective of this study is to investigate the effectiveness of the AWHP system in terms of both the system’s energy use and the extent to which the system has sufficient capacity to meet the space heating demand of the buildings. As a result of the study, the paper reveals that only 482 house archetypes (with their current level of thermal insulation) are eligible for the AWHP retrofit

The influence of halides in polyoxotitanate cages; dipole moment, splitting and expansion of d-orbitals and electron-electron repulsion

Metal-doped polyoxotitanate (M-POT) cages have been shown to be efficient single-source precursors to metal-doped titania [TiO$_2$(M)] (state-of-the-art photocatalytic materials) as well as molecular models for the behaviour of dopant metal ions in bulk titania. Here we report the influence halide ions have on the optical and electronic properties of a series of halide-only, and cobalt halide-‘doped’ POT cages. In this combined experimental and computational study we show that halide ions can have several effects on the band gaps of halide-containing POT cages, influencing the dipole moment (hole–electron separation) and the structure of the valance band edge. Overall, the band gap behaviour stems from the effects of increasing orbital energy moving from F to I down Group 17, as well as crystal-field splitting of the d-orbitals, the potential effects of the Nephelauxetic influence of the halides and electron–electron repulsion.We thank the EPSRC (Doctoral Prize for P. D. M.), A*STAR Singapore (Scholarship for N. L.), the Studienstiftung des deutschen Volkes, Fonds of the Chemical Industry (S. H.) for funding. The authors would like to acknowledge the use of the EPSRC UK National Service for Computational Chemistry Software (NSCCS) at Imperial College London and contributions from its staff in carrying out this work